Prof. Dr. Jabbar A. A. Al-Saedi, a lecturer at the College of Dentistry at Al-Ayen Iraqi University, published scientific research entitled (The Repro-prophylactic Impact of Synthetic Tocopherol Polyethylene Glycol, Succinate-Coated, Garlic-Selenium Nanoparticles against Lead Acetate Toxicity in Male Rabbits) in the (Baghdad Science Journal) included in the Scopus and Clarivate indexes. The study included highlighting the impact of industrial and human activities, including lead as one of the hazardous heavy metals widely present in the environment, which poses a threat to public health and ecosystems. Since garlic extract has preventive importance against many functional disorders, the study included testing its effect against heavy metal toxicity. The research hypothesis revolved around the possibility of loading the components of garlic plant extract onto nanoparticles to ensure higher effectiveness by delivering the extract components into the cells. The present study investigated the role of nanoparticles synthesized from tocopherol glycol-succinate encapsulated garlic and selenium (TPGS-GSNP) in protecting the reproductive system of male rabbits from lead poisoning. To achieve the objectives of the study, the levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, and gonadotropin-releasing hormone (GNRH) were measured. The histopathological data of the testes and the expression level of FSHβ and LHβ genes in the pituitary, FSH, and LH receptor genes, ABP, 3β-HSD, 17β-HSD, and Inh-α genes in the testes were evaluated. The group treated with lead acetate showed obvious histopathological changes with a significant decrease in the levels of hormones and the expression level of pituitary and testicular genes. The treatment with TPGS-GSNP nanoparticles with or without lead acetate showed a significant improvement. The study concluded that the synthesized TPGS-GSNP nanoparticles have a positive effect against the effects of lead poisoning on the induced reproductive system in mature male rabbits The subject requires further research to explore the mechanism of action of TPGS-GSNP nanoparticles.
